Can TMS Be Used to Treat Alzheimer's Disease?
Alzheimer’s disease is a complex brain disease that results in the progressive deterioration of one’s cognitive, emotional, and behavioral capacities. The condition affects nearly six million people in the United States age 65 and older.
Though there is no cure for AD, many treatments offer some amount of symptom reduction. While they are effective to some degree, there is much room for improvement.
In recent years, researchers have been exploring alternative ways of addressing the range of impairments caused by AD. In particular, they have explored whether transcranial-magnetic stimulation (TMS), a non-invasive, nonpharmacological procedure often used for psychiatric conditions such as treatment-resistant depression, may prove useful against the cognitive and emotion impairments experienced by individuals with AD.
If effective, this novel application of TMS could help AD patients maintain their capacities and improve their quality of life. Does the evidence support its use?
Transcranial magnetic stimulation is a drug-free and noninvasive procedure used to treat various brain disorders, including several mental health conditions. It uses magnetic coils placed just above the scalp to send magnetic pulses into specific regions of the brain associated with symptoms of the condition it is being used to treat. For example, in the case of treatment-resistant depression, the pulses are sent toward regions of the brain associated with mood regulation.
By sending repeated pulses to these specific areas of the brain, TMS “trains” neurons in those locations to fire differently and create new, healthier connections.
TMS has been used to treat a wide range of issues associated with AD with varying degrees of efficacy and evidence backing its use.
Though Alzheimer’s disease is mainly known for its effects on memory and cognition, it can also cause disruptions in mood and emotional regulation. For example, up to fifty percent of individuals with AD suffer from depression.
Though the high prevalence of depression in AD patients is partially attributable to the stress of having the disease, it is likely also to be the direct result of the disease’s biological effects. For example, post-mortem studies have found that AD patients with depression were more likely to have lost neurons that respond to chemical messengers commonly targeted by anti-depressants, such as serotonin and norepinephrine.
Several studies have found that AD patients treated with TMS experience improvements in their mood. For example, TMS has been associated with lower scores of depression and apathy among individuals with AD. This finding is supported by the fact that the treatment protocol for AD often targets the same brain area as the protocol for treatment-resistant depression, namely the left dorsolateral prefrontal cortex (L-DLPFC).
Regarding cognitive symptoms, researchers are actively investigating whether and how much TMS helps. In particular, they have examined the effects of TMS on the following:
While several studies have found positive results, others have failed to find a significant effect. Explaining this is difficult mainly because different researchers have utilized different protocols on different parts of the brain in patients at different disease stages. As a result, it is hard to determine whether the results are inconsistent because the treatment does not work or because some researchers are targeting the right areas in the right ways in the right patients while others are not.
Researchers have attempted to comb through the data to find patterns in when the treatment does and does not work. One finding that emerged most clearly is that TMS does not work in patients with more advanced AD, suggesting that if the treatment works at all, its efficacy depends on the individual’s disease stage.
Even among the studies that have found positive results, patients may have improved for reasons that had nothing to do with the direct effect of TMS on AD. For example, improvements in depression are associated with gains in cognitive performance. Since TMS tends to alleviate depression in AD patients, this could explain why their cognitive symptoms improved and not that TMS treated the part of their cognitive dysfunction caused by their AD.
Another issue stems from how the studies measure the subjects’ cognitive abilities. To determine whether symptoms improved over time, researchers had AD patients repeatedly take tests and perform tasks that allowed them to track how their performance changed as they continued to receive TMS. The problem with this method is that patients may get better with practice alone. This means we can’t be sure how much the positive effects are attributable to practice or to the impact of TMS on AD itself. While some studies included a control group that took the cognitive assessments while being given “sham” TMS, which does not stimulate the brain, the results were unclear.
So, does TMS work for Alzheimer’s disease? That depends in part on what symptoms we are concerned with. As far as depression goes, TMS appears to work just as well in AD patients. However, the results are less clear when it comes to cognitive impairments. Confounding variables and a lack of consistency in treatment protocols mean it’s too early to draw any confident conclusions.
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